Structure of PDB 7q8q Chain AA Binding Site BS01

Receptor Information

>7q8q Chain AA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LPKSVDWRKKGYVTPVKNQKQCGSSWAFSATGALEGQMFRKTGKLVSLSE
QNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKY
RPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSG
IYFEPDCSSKNLDHGVLVVGYGFEGANSQNSKYWLVKNSWGPEWGSNGYV
KIAKDKNNHCGIATAASYPNV

Ligand information

>7q8q Chain PA (length=5) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RLSAK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7q8q Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins.
Resolution	2.13 Å
Binding residue (original residue number in PDB)	C22 G23 G140 Q145 D163 H164 W190
Binding residue (residue number reindexed from 1)	C22 G23 G140 Q145 D163 H164 W190

Enzymatic activity

Enzyme Commision number

3.4.22.43: cathepsin V.

Gene Ontology

	Molecular Function
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:7q8q, PDBe:7q8q, PDBj:7q8q
PDBsum	7q8q
PubMed	37095140
UniProt	O60911\|CATL2_HUMAN Cathepsin L2 (Gene Name=CTSV)

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