Structure of PDB 7pzy Chain AA Binding Site BS01

Receptor Information

>7pzy Chain AA (length=135) Species: 237561 (Candida albicans SC5314)

AKFIKSGKVAIVVRGRYAGKKVVIVKPHDEGTKSHPFPHAIVAGIERAPL
KVTKKMDAKKVTKRTKVKPFVKLVNYNHLMPTRYSLDVESFKSAVTSEAL
EEPSQREEAKKVVKKAFEEKHQAGKNKWFFQKLHF

Ligand information

>7pzy Chain 1 (length=3209)

ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcg
gaggaauguggcacggcuucugcuguguguuauagccucugacgauacug
ccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaauga
ucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugc
gaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugg
gggcccauuagggugcaccaucgaccgauccugauguguucggauggauu
ugaguaagagcauagcuguugggacccgaaagauggugaacuaugccuga
auagggugaagccagaggaaacucugguggaggcucguagcgguucugac
gugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaac
caucuaguagcugguuccugccgaaguuucccucaggauagcagaagcuc
guaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaa
ugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcu
uaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugg
uaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccg
gaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagc
cggacgguggccauggaagucggaauccgcuaaggaguguguaacaacuc
accggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuac
uuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcg
uggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucu
agugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaaga
cugaaguggggaaagguuccaugucaacagcaguuggacauggguuaguc
gauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggc
caaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauu
cuucacggcaacguaacugaauguggagacgucggcgugagcccugggag
gaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccg
gagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggu
gcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugcc
aagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguu
gauagaauaauguagauaagggaagucggcaaaauagauccguaacuucg
ggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgc
gaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugg
uacggacaaggggaaucugacugucuaauuaaaacauagcauugugaugg
ucagaaagugauguugacacaaugugauuucugcccagugcucugaaugu
caaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaug
acucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaug
aauggauuaacgagauucccacugucccuaucuacuaucuagcgaaacca
cagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguu
gagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaa
gcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcga
uccggguugaagacauugucagguggggaguuuggcuggggcggcacauc
uguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaa
ucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagug
ugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaa
uuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuugug
gcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcu
cuuccuaucauaccgaagcagaauucgguaagcguuggauuguucaccca
cuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuu
uacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagag
gaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacg
ccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaa
uccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacg
aauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuu
agcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgc
ggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaag
caguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugu
cugauuugu

.......................<<<<<<.....<......>......>>
>>>.>.........<<....>>..<<<<<......<<.....>>.....>
>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.
....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>
>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<......<.
....>......>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<
<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>
>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>
>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<
..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<
..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>
>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<
<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<.
.......>>>>>>>>....>>>>>>>>>...<<.......>>......>>
>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<
...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<....
.>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<.
.....>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.
....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.
....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<
<<<.<<....<<.........>>....>>.........<<......>>..
.>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>
>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..
<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>
>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<
<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<
<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>
......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.
....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<
<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>
....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.
..>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>
>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>
..<<<<.....<<<<<<<.<<.........<.....<<<<<.........
......>>>>><<.<<<<<<<<<<<..<<<<<.<<.....<<<.<<<..<
..>.>>>.>>>......>>>>>.>>.......>>>>>..>>>>>>.>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<
<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<
.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......
>>>>>>........<...........<<<<<.......>>>>>.....>.
....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>.
...<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{
{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<....
.<<<<..<<<<<......>>>>>..............<<<<...>>>>..
>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<
<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......
>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<......
.>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>
>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<
<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.
<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}
}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<............
.....>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>
>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...
>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<.....
.....<<<<....>>>>......>>.......<<<<<<...<<<<<<<..
<<<......>>>..>>>>>>>.>>>>>>................>>>.>>
>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<
<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>
..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pzy E-site drug specificity of the human pathogen Candida albicans ribosome.
• Resolution: 2.32 Å
• Binding residue (original residue number in PDB): G16 R17 H36 F38 R48 T54 K55 K64 R65 K69 K73 L74 N76 H79 R107 E108 K111 K115 K133 H135 F136
• Binding residue (residue number reindexed from 1): G15 R16 H35 F37 R47 T53 K54 K63 R64 K68 K72 L73 N75 H78 R106 E107 K110 K114 K132 H134 F135

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7pzy, PDBe:7pzy, PDBj:7pzy
• PDBsum: 7pzy
• PubMed: 35613268
• UniProt: A0A1D8PFG4|RL27A_CANAL Large ribosomal subunit protein eL27 (Gene Name=RPL27A)