Structure of PDB 8ove Chain A4 Binding Site BS01

Receptor Information
>8ove Chain A4 (length=198) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPHLRKLRKLKRANPSQEEESVARVLFELEGSHKTLRAQLPRFHINTVRT
SSSPRHKKTAMIILYPLRFIMLVRKIQRTLTAELEKRFPGNIVVLVAQRK
ITKRPNDVYKLQQVQRSRTSVAVFENILNDLIYPCDVVGRRWRYRTDGSK
LMKVFLDARDRKRVESRLPLLAHVYKLLTHRTVTFGFMWNPKLQQVSS
Ligand information
>8ove Chain AA (length=1836) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcgcaggaaucugcgcauggcucauuacau
cagacguaaucugccgccaaaauuuugcgcauuacuggauaacuuggcga
aacgccaagcuaauacaugaaccaaucggacgcucucuuugggacgucca
gcgaaugaaugaaaccaacgccuccggaggcaguaacacucagacguguu
gacucaauucauuccgugcgaaagccgagcugcucggcgucuacugacga
acaacugcccuaucagccagugauggccguguaguggacugccauggcgu
ugacgggagcgggggauuaggguucgauuccggagagggagccugagaaa
uagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucg
aaaaaauacgaugaggcagcgaaaagaaauagagccgaccgugugguugu
uuucaaugggggauacucaaacccauucaauaucgaguaacaauuggagg
acaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauau
uaaugcuguugcuguuaaaggguucguaguugaacugugggccacguagu
guggugccguaccagucccguaccucgacguguuuugacccacgcccucg
uggcccagauacagaaacacgggagcaguucgcaugucaugcaugggcgu
ccgugaauuuuacugugaccaaaaagaugcgaccaaagcaguuugccgac
uugaauuacaaagcaugggauaacgaagcaucagcccugggguuauguug
guuuuagaaguccuugggagauuauggggccgccgcgcggcuucgaauga
aggaggguaguucgggggagaacguacuggugcgucagaggugaaauucu
uagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuu
ccucaaucaagaaccaaaguguggggaucaaagaugauuagagaccauug
uaguccacacugcaaaccaugacacccaugaauuggggagugccucucag
cacguuucuuacuucuucacgcgaaagcuuggagguuacagucucagggg
ggaguacguucgcaagagugaaacuuaaagaaauugacggaauggcacca
caagacguggagcgugcgguuuaauuugacucaacacggggaacuuuacc
agauccggacagggugaggauugacagauggaguucuuucucgauccccu
gaaugguggugcauggccgcuuuuggucgguggagugauuuguuugguug
auuccgucaacggacgagauccaagcugcccaguaggugccgggauuguc
cacacaggacagcauccuucuuuaggccccuucucugcgggauuccuugc
uuuucgcgcaaggugagauuuugggcaacagcaggucugugaugcuccuc
aauguucugggcgacacgcgcacuacaaugucagugagaacaagagucga
cgcucccgcuugaucaaaagagcggggaaaccacggaaucacguagaccc
acuugggaccgaguauugcaauuauuggucgcgcaacgaggaaugucucg
uaggcgcagcucaucaaacugugccgauuacgucccugccauuuguacac
accgcccgucguuguuuccgaugauggugcaauacaggugaucggaccgu
caccgaaaguucaccgauauugcuucaauagaggaagcaaaagucguaac
aagguagcuguaggugaaccugcagcuggaucauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<..>>>...>>.>>......<<........
<<<..<<..<<...<<..<................<<.....<<<<<<..
...>>>>>>......>>..........<<<<<.<<<.....>>>>>>>>.
<<<<<<<<<<....(((((<<<<....>>>>...................
......>>>>>>>>...>>....<<<<<<<.>>>>>>>...>..>>..>>
>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>..
....>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<........
..>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<.
.........>>>..>>>..>....>>>....<<<................
.>>>.......<..............>................<<<<<((
....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>
>>.........<<<[[.....<<<<...<<<.......<<<<...<...<
..<<....<<..<.<.........>.>..>>..>>.>...>..>>>>...
................<<.........<<....<<.......>>..>>..
..>>....<<..<...........<...<<.......>><<<<....>>>
>....>............>..>>...........<<..<<<.<<<.))))
)..>.>>...>>>..>>........<<..<.<.....>>...>>......
....<<<<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>.
.....>>>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>
....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>>.........<<<.<<...<..<.<<<<<<<<<......>
>>>.>>>>>.>..>......<<..]]>>.....>>.....>>>.>>>.<<
<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<
<.<<<<<<..<<.<<<<<<<......<<........>>..........<<
<<<.<....<<<<<........<<.<<<......>>>.>>......>>>>
>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<...
...>>>...>>.>>>....<<<<<.<<<<.....<<<.<<<<<<<.....
..................>>>>..>>>.>>>.....>>>>....<<<<<<
.......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>..
...>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<....<.
..>.<<<<<<<........>>>>>>>....>........>>>...>>>..
....<....<<<.<<..........>>.>>>.....>.....>>>>>>..
..<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.
...<..<<.<.<<<<<<<<..<<.<<<.<<<<<<..<<<<<.<...<...
....>...>.>>>>>..>>>>>>.>>>.>>..>>>>>>>>..>.>>...>
.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R11 K12 L13 K14 R45 L70 R71 M74 L75 Q101 R102 K103 I104 R107 Y112 Q115 R119 S120 R121 T122 S123 V124 K179 H183
Binding residue
(residue number reindexed from 1)		R8 K9 L10 K11 R42 L67 R68 M71 L72 Q98 R99 K100 I101 R104 Y109 Q112 R116 S117 R118 T119 S120 V121 K176 H180
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ38FD9

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