Structure of PDB 6zm6 Chain A4 Binding Site BS01

Receptor Information

>6zm6 Chain A4 (length=588) Species: 9606 (Homo sapiens)

EEVVIPKKKTWDKVAVLQALASTVNRDTTAVPYVFQDDPYLMPASSLESR
SFLLAKKSGENVAKFIINSYPKYFQKDIAEPHIPCLMPEYFEPQIKDISE
AALKERIELRKVKASVDMFDQLLQAGTTVSLETTNSLLDLLCYYGDQEPS
TDYHQFGVTWRAKNNAERIFSLMPEKNEHSYCTMIRGMVKHRAYEQALNL
YTELLNNRLHADVYTFNALIEATVCAINEKFEEKWSKILELLRHMVAQKV
KPNLQTFNTILKCLRRFHVFARSPALQVLREMKAIGIEPSLATYHHIIRL
FDQPGDPLKRSSFIIYDIMNELMGKRFSPKDPDDDKFFQSAMSICSSLRD
LELAYQVHGLLKTGDNWKFIGPDQHRNFYYSKFFDLICLMEQIDVTLKWY
EDLIPSAYFPHSQTMIHLLQALDVANRLEVIPKIWKDSKEYGHTFRSDLR
EEILMLMARDKHPPELQVAFADCAADIKSAYESQPIRQTAQDWPATSLNC
IAILFLRAGRTQEAWKMLGLFRKHNKIPRSELLNELMDSAKVSNSPSQAI
EVVELASAFSLPICEGLTQRVMSDFAINQEQKEALSNL

Ligand information

>6zm6 Chain y (length=19)

uuuaagaacguguuuauuu

...................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zm6 Mechanism of membrane-tethered mitochondrial protein synthesis.
• Resolution: 2.59 Å
• Binding residue (original residue number in PDB): R343 R377 Q417 H453 F456
• Binding residue (residue number reindexed from 1): R265 R299 Q339 H375 F378

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0043024 ribosomal small subunit binding

Biological Process

• GO:0006417 regulation of translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zm6, PDBe:6zm6, PDBj:6zm6
• PDBsum: 6zm6
• PubMed: 33602856
• UniProt: Q96EY7|PTCD3_HUMAN Small ribosomal subunit protein mS39 (Gene Name=PTCD3)