Structure of PDB 7og4 Chain A3 Binding Site BS01

Receptor Information

>7og4 Chain A3 (length=69) Species: 9606 (Homo sapiens)

KNVLKIRRRKMNHHKYRKLVKKTRFLRRKVQEGRLRRKQIKFEKDLRRIW
LKAGLKEAPEGWQTPKIYL

Ligand information

>7og4 Chain AA (length=924)

auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaaca
agcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacc
cccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaac
uaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggu
cacacgauuaacccaagucaauagaccggcguaaagaguguuuuagauca
caauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaa
auagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagac
ccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacagu
ucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaa
ggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucga
uaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccauc
uucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaa
agacguuaggucaagguguagcccaugagguggcaagaaaugggcuacau
uuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauu
uagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgc
guacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacua
aaaccccuacgcauuuauauagaggagacaagucguaacaugguaagugu
acuggaaagugcacuuggacgaac

..((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<
..<......>......<<........<<<.<..<<..>>.>..>>>...<
<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<
<....>>>.....>>>>>>>........<<<....<<<......>>>..>
>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>))...
....)))..>>>>>...>.>>>>>>..<<<((.....<<<<..<<<<...
...<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>......
.......<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<..
.<<...<<<<.........>>>>...>>>>>>>>..........<.<<<<
<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>
>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<.
.......>>..........<<<<<<<.......<<.<<<..<<<<<<.<.
....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.
....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>....
.<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>.....>>
>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>
>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....
>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<
<<<....>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7og4 Structural basis of mitochondrial translation.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): K128 N129 L131 K132 I133 R134 R136 K137 M138 N139 H141 K142 Y143 R144 K145 L146 V147 K148 R151 R155 R161 R164 K165 K171 Y195
• Binding residue (residue number reindexed from 1): K1 N2 L4 K5 I6 R7 R9 K10 M11 N12 H14 K15 Y16 R17 K18 L19 V20 K21 R24 R28 R34 R37 K38 K44 Y68

Gene Ontology

Molecular Function

• GO:0005515 protein binding

Biological Process

• GO:0032543 mitochondrial translation
• GO:0045839 negative regulation of mitotic nuclear division
• GO:0045862 positive regulation of proteolysis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:0043231 intracellular membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7og4, PDBe:7og4, PDBj:7og4
• PDBsum: 7og4
• PubMed: 32812867
• UniProt: Q9NWT8|AKIP_HUMAN Small ribosomal subunit protein mS38 (Gene Name=AURKAIP1)