Structure of PDB 7ls2 Chain A3 Binding Site BS01

Receptor Information

>7ls2 Chain A3 (length=144) Species: 10090 (Mus musculus)

SLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADID
LTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLAN
GLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT

Ligand information

>7ls2 Chain m2 (length=1724)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugaccccccuucccggggggg
gaugcgugcauuuaucagauggugacucuagauaaccucgggccgaucgc
acgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuu
ucgaugguagucgccgugccuaccauggugaccacgggugacggggaauc
aggguucgauuccggagagggagccugagaaacggcuaccacauccaagg
aaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugac
gaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguc
cacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccag
cagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguu
aaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggcg
gggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccg
agccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucua
uuuuguugguuuucggaacugaggccaugauuaagagggacggccggggg
cauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacgg
accagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaa
gucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacg
augccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcu
uccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcu
gaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcgg
cuuaauuugacucaacacgggaaaccucacccggcccggacacggacagg
auugacagauugauagcucuuucucgauuccgugggugguggugcauggc
cguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacga
gacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccc
caacuucuuagagggacaaguggcguucagccacccgagauugagcaaua
acaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacug
acuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguu
gaaccccauucgugauggggaucggggauugcaauuauuccccaugaacg
aggaauucccaguaagugcgggucauaagcuugcguugauuaagucccug
cccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugag
gcccucggaucggccccgccggggugcccuggcggagcgcugagaagacg
gucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccgua
ggugaaccugcggaaggaucauua

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<...<....<<....<<..........>>...>>.>.......<<...
.....<<<.<.<..<<....<<<<<.........<<..<...<..<....
...>..>......>>>.........<<<<...<<<<<<<....>>>>>>>
...>>>><<..<<<<<....<......>..>>>>>......>>...<<<<
.<<<<......>>>>>>>>.>>.>>>...>>>.>.>>>.<<<....<<<.
.....<<<<<.........>>>>>..>>>......>>>...<<<.<<<<.
...>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>
>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...
>>.>.....<<<<<<<<<.<<.......>>.>>>>>.>>>>......<<.
.<...........>..>>.........<<<<<((......<<<<.....<
<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((
.....<.<<...<<<.............<<<..>>>.....<..<.....
.......>.>...<<<<<<.<.......<<...<.......>..<<....
.....>.>...>>......>.>>>..>>>........<.<..<<<<<<<.
..............>>>>>>>..>.>..........<<<<<<..<...<<
<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.
......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....
<<<<<<....<...<<<<.........>>>>...>.>>>>>>........
..<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>
...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>
....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<.<<<<.<<<<<
<......<<........>>..........<<<<<......<<<<<.....
...<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<
<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>..
..<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>....
.>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>
>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.>...<
<.<<<........<.......<<<<<<<<....>>>>>>>>....>....
.....>>>.>>............<<<<<..........>>>>>.......
....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>
>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<...
<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>
>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<
<<<..>>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ls2 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): K25 F28 K34 G37 R38 R39 Y40 W82 F83 N85 Q87 L103 D110 H120 R121 R124 H125 L129 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 R141 R144 T145
• Binding residue (residue number reindexed from 1): K24 F27 K33 G36 R37 R38 Y39 W81 F82 N84 Q86 L102 D109 H119 R120 R123 H124 L128 R129 V130 R131 G132 Q133 H134 T135 K136 T137 T138 R140 R143 T144

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0014069 postsynaptic density
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0045202 synapse
• GO:0098794 postsynapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ls2, PDBe:7ls2, PDBj:7ls2
• PDBsum: 7ls2
• PubMed: 34815424
• UniProt: P62270|RS18_MOUSE Small ribosomal subunit protein uS13 (Gene Name=Rps18)