Structure of PDB 8ova Chain A2 Binding Site BS01

Receptor Information
>8ova Chain A2 (length=183) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAKAPKLFNKWSYENLQTTEIALNDYITRTPTYVPHSAGRWQKKRFRKAR
IPIVERLTNGLMFKGRGNGKKLQAVRLVRHTLEIIHLLTDQNPIQVVIDA
VSKGAPREDSTRVRRQAVDVSPMRRVNEAIYLMCKGAREAAFRNLKTLPE
CLADEIVNASKGSSNSYAIKKKDEVERVAKANR
Ligand information
>8ova Chain AA (length=1919) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcauugcaggaaucugcgcauggcucauua
caucagacguaaucugccgccaaaauuuugcggcgcauuacuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuugaug
ggacguccagcgaaugaaugaaauuagaaccaacgccuccacccggaggc
aguaacacucagacguguugacucaauucauuccgugcgaaagccgagcu
gcucggcgucuacugacgaacaacugcccuaucagccagugauggccgug
uaguggacugccauggcguugacgggagcgggggauuaggguucgauucc
ggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcg
cgcaaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaaua
gagccgaccgugugguuguuuucaaugggggauacucaaacccauucaau
aucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuc
cagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucguaguu
gaacugugggccacguaguguggugccguaccagucccguccaccucgac
guguuuugacccacgcccucguggccagauacaagaaacacgggagcagu
ucgcaugucaugcaugggggcguccgugaauuuacugugaccaaaaagau
gcgaccaaagcagucuugccgacuugaauuacaaagcaugggauaacgaa
gcaucagcccugggguuauguugguuuuagaaguccuugggagauuaugg
ggccgcguuguuucguguggcgcgccgcggcuuccaggaaugaaggaggg
uaguucgggggagaacguacuggugcgucagaggugaaauucuuagaccg
caccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaau
caagaaccaaaguguggggaucaaagaugauuagagaccauuguagucca
cacugcaaaccaugacacccaugaauuggggaacaucauuuuauuuauca
auuuacgugccuacucagcacguuucuuacuucuucacgcgaaagcuugg
agguuacagucucaggggggaguacguucgcaagagugaaacuuaaagaa
auugacggaauggcaccacaagacguggagcgugcgguuuaauuugacuc
aacacggggaacuuuaccagauccggacagggugaggauugacagaugga
guguucuuucucgauccccugaaugguggugcauggccgcuuuuggucgg
uggagugauuuguuugguugauuccgucaacggacgagauccaagcugcc
caguaggugccgggauuguccacacaggacagcaguccucgucauccuuc
uuuuuucaggccccuucucugcgggauuccuugcuuuucgcgcaagguga
gauuuugggcaacagcaggucugugaugcuccucaauguucugggcgaca
cgcgcacuacaaugucagugagaacaagagcgacgcucccgcuugaucaa
aagagcggggaaaccacggaaucacguagacccacuugggaccgaguauu
gcaauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaa
acugugccgauuacgucccugccauuuguacacaccgcccgucguuguuu
ccgaugauggugcaauacaggugaucggaccgucaccgaaaguucaccga
uauugcuucaauagaggaagcaaaagucguaacaagguagcuguagguga
accugcagcuggaucauuu
...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[
.[[[..<<....<<....<<<<...>>>>...>>.>>......{{.....
...[[[..[[..[[...[[..{......<<<<.>>>>....<<.....<<
<<<<.....>>>>>>......>>..........<<<<<.<<<<<<.>>.>
>>>>>>>>.[[((((((((.....<<<<<<<<<<<<<<<......>>>>>
.........................))))))))...]]....<<<<<<<.
>>>>>>>...}..]]..]]]]..]]].<<<....<<<....<<<<<.<<.
......>>.>>>>>>>>......>>>..<<<.<<<<....>>>>....>>
>.}}.<<.<<<..........>>>.>>.<<<<<..>>>>>...]]]]]].
........<<<....<<<..........>>>..>>>.......]]]....
<<<...<.<.....>.>...>>>.....<.<..............>....
..>.........<<<<<((....<.<<<<.....<<..))>>.......>
>>>>>>>>>..]]]]]]}}}}.........[[[[[.....((((...(((
.......<<<<...<...<..<<....<<..<.<...........>.>..
>>..>>.>...>..>>>>.................<...<<........<
...<<<.......>>>.>...>>...>...<<..<...........<...
<<.......>>..<......>.......>..........>....>>....
.......[[..(((.....>>>>>>>>>>....)))..]]........<<
<<<<<<<....<<<..>.>>.....>>>>>>>>>.............<<<
<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>
>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....)))
...))))...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>
>>>>.........<<<.<<...<..<.<<<<<..................
......<<<<.......>>>>.>>>>>.>..>......<<..]]>>....
.>>.....>>>.]]].<<<......<<<<....>>>>....>>>..}}}}
..<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<....
....>>..........<<<<<.<....<<<<<........<<.<<<....
....>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<
<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.
....<<<.<<<<<<................................>>>.
........>>>.>>>.....>>>>....<<<<<<<....>.>>>>>>...
....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.
>>>>>.>>.....<<<.<<<.......<...<....><<<<<<<......
..>>>>>>>....>........>>>...>>>......<....<<<.<<..
........>>.>>>.....>.....>>>>>>....<<<<<<<........
.>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<
<<..<<.<<<.<<<<<<..<<<<<.<...<.<<.>>.>...>.>>>>>..
>>>>>>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		H37 Q43 R46 K49 N60 F64 R67 N69 G70 K71 K72 Q74 R77 N134 Y138 R150 L152 L155
Binding residue
(residue number reindexed from 1)		H36 Q42 R45 K48 N59 F63 R66 N68 G69 K70 K71 Q73 R76 N127 Y131 R143 L145 L148
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ385D9

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