Structure of PDB 7oyb Chain A2 Binding Site BS01

Receptor Information

>7oyb Chain A2 (length=210) Species: 7955 (Danio rerio)

GGLDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYVYKRKSDGVYIINLK
KTWEKLLLAARAIVAIENPADVCVISSRNTGQRAVLKFASATGSTTFAGR
FTPGTFTNQIQAAFREPRLLIVTDPRADHQPLTEASYVNIPTIALCNTDS
PLRYVDIAIPCNNKGPHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLY
FYRDPEEIEK

Ligand information

>7oyb Chain 22 (length=1502)

uaccugguugauccugccaguaauauaugcuugucucaaagauuaagcca
ugcaagucuaagugcacacgagugaaacugcgaauggcucauuaaaucag
uuaugguuccuuugaucacuuggauaacuguggcaauuccagagcuaaua
caugcgccgcgugcauuuaucaguggugacucuagauaacgccgaucgcg
cgcgcggcgacgguucauucgaaugucugcccuaucaacuuucgauggua
gguccgucgccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccauuuccgacacggagagguagugacgaaaaauaa
caauuuggaaugagugcaucccaaacccaugggcgaggacccauuggagg
gcaagucuggugccagcagccgcgguaauuccagcuccaauagcguaugc
uaacguugcugcaguuaaaaagcucguaguuggaucucuuuacuuugaaa
aaauuagaguguucaaggcagggccccccauugaauaccccagcuaggaa
uaauggaauaggaccccggggccaugaucgagagggacggccgggggcau
ucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggacc
ggagcgaaagcguuugccaagaacguuuucauuaaucaagaacgaaaguc
ggagguucgaagacgaucagauaccgucguaguuccgaccguaaacgaug
ccgacccgcgauccggcggcguuugacccgccgggcagcguugcgggaaa
ccacgagucucugggcuccggggggaguaugguugcaaagcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gacucaacacggggaaccucacccggcccggacaauugacagauucucga
uucugugggugguggugcauggccguucguaguugguggagcgauuuguc
ugguugauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcg
gccggucggcguaacuucuuagagggacaaguggcguucagccacgcgag
acugagcaauaacaggucugugaugcccuuagauguccggggcugcacgc
gcgccacaaugggcggaucaacguguccugcgccgacaggcgcggguaac
ccguugaaccccgcccgugauggggaccgauugaaacuauuucccgagaa
cgaggaauucccaguaagcgcaggucaucagcuugcguugauuaaguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauugagcggcucagug
agguccucggaucggcgccgagaagacgaucgaacucggucguuuagagg
aaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau
ua

...<<<<<.[.((((>>>>><<.<<<<<<<...<.<<..<......<<<.
<<<..<<....<<.............>>.>>......<<........<<<
.<<<..<<....<..<....<<.....<<.<<<.....>>>.>>......
>>..............<<<<<...<......>..>>>>>......<<<..
<....>.>>>..>...>...>>>>>.>>>.<<<....<<<.....<<<<<
<<.......>>>>>>>.>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....
<<...>>......<<.<<<.........>>>.>>.........<.<<<((
......<<<......<<..))>>........>>>.>>>.>..>>>>>>>.
>>.........<.<((.....<.<<...<<<.<<.....<<<<<<.<...
....<<...<.......>...<<...>>.......>>......>.>>>..
>>>..........<<<..>>>......>>....<<<<<<..<...<<<<.
.<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>....
...<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<
<<<<...<...<<<<.........>>>>...>>>>>>>>..........<
<<.<<.<<<..<<<<<<<<.<<<.>>>>>>>>>>>..>>>....<<..))
>>....>>.....>>>.>.>.<<<......<<<......>>>....>>>.
.)))).]<<<<<.<<<<<<<..<<..<<<<<....<<............<
<........>>..........<<.<<...........<<.....>>....
........<.<..<<<..<<.<<<<<<....<<<.<<<<<....>>>...
<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<..<<<
<<..>>>.>>..>>>>..>>>>..>.....<<<<<.....>>>>>.....
...>>>....>>>.>>>.....>>>>>.>>......>>.>>.........
>.>.......<<<<<<........<.<<<<<<<<....>>>>>>>>....
>.........>>>>>>............<<..........>>........
......>>>>>.....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<.
.<<<<.<<...<<<<..>>>>...>>.>>>>..>>>.>>>>>>>>...>>
.>>>>...>.>>.........<<<<<<<<<<..>>>>>>>>>>.......
..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oyb A molecular network of conserved factors keeps ribosomes dormant in the egg.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): F32 R41 R102 T104 P105 T109 N110 I112 Q113 Q132 E136 Y139 R155
• Binding residue (residue number reindexed from 1): F30 R39 R100 T102 P103 T107 N108 I110 Q111 Q130 E134 Y137 R153

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005055 laminin receptor activity
• GO:0043236 laminin binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0007155 cell adhesion

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:0015935 small ribosomal subunit
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oyb, PDBe:7oyb, PDBj:7oyb
• PDBsum: 7oyb
• PubMed: 36653451
• UniProt: Q803F6|RSSA_DANRE Small ribosomal subunit protein uS2 (Gene Name=rpsa)