Structure of PDB 5nmb Chain A2 Binding Site BS01

Receptor Information

>5nmb Chain A2 (length=238) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HMLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRLSMLPHLADLVSY
SIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSW
SCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAI
CLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKLA
DLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEV

Ligand information

>5nmb Chain B2 (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RHKILHRLLQE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5nmb Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	I270 K274 I288 K292 E446 V447 E451 V452
Binding residue (residue number reindexed from 1)	I56 K60 I74 K78 E232 V233 E237 V238

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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External links

PDB	RCSB:5nmb, PDBe:5nmb, PDBj:5nmb
PDBsum	5nmb
PubMed	28399453
UniProt	Q9PTN2\|VDRA_DANRE Vitamin D3 receptor A (Gene Name=vdra)

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