Structure of PDB 8ova Chain A0 Binding Site BS01

Receptor Information
>8ova Chain A0 (length=220) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAMSRKEWYDVVAPKNFEVRQFAKTICNKTQGTKIAADFLRGRVYEGNLA
DLNKNEDDAYRKVKFTVQEVQGRNLLTQFHGMDMTSDRVYYLLRKWCTTI
EATVEAKTADGYGLRLFLIAFTKKQENQLSKNCYAKTRLVKWVRMRATNI
IRRRLAKLDINDAVSLLTRNILRDRLAKRCNPIIPLRDLRIRKVKVIRTP
KFDAQALIAAHGEVPTSAEG
Ligand information
>8ova Chain AA (length=1919) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcauugcaggaaucugcgcauggcucauua
caucagacguaaucugccgccaaaauuuugcggcgcauuacuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuugaug
ggacguccagcgaaugaaugaaauuagaaccaacgccuccacccggaggc
aguaacacucagacguguugacucaauucauuccgugcgaaagccgagcu
gcucggcgucuacugacgaacaacugcccuaucagccagugauggccgug
uaguggacugccauggcguugacgggagcgggggauuaggguucgauucc
ggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcg
cgcaaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaaua
gagccgaccgugugguuguuuucaaugggggauacucaaacccauucaau
aucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuc
cagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucguaguu
gaacugugggccacguaguguggugccguaccagucccguccaccucgac
guguuuugacccacgcccucguggccagauacaagaaacacgggagcagu
ucgcaugucaugcaugggggcguccgugaauuuacugugaccaaaaagau
gcgaccaaagcagucuugccgacuugaauuacaaagcaugggauaacgaa
gcaucagcccugggguuauguugguuuuagaaguccuugggagauuaugg
ggccgcguuguuucguguggcgcgccgcggcuuccaggaaugaaggaggg
uaguucgggggagaacguacuggugcgucagaggugaaauucuuagaccg
caccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaau
caagaaccaaaguguggggaucaaagaugauuagagaccauuguagucca
cacugcaaaccaugacacccaugaauuggggaacaucauuuuauuuauca
auuuacgugccuacucagcacguuucuuacuucuucacgcgaaagcuugg
agguuacagucucaggggggaguacguucgcaagagugaaacuuaaagaa
auugacggaauggcaccacaagacguggagcgugcgguuuaauuugacuc
aacacggggaacuuuaccagauccggacagggugaggauugacagaugga
guguucuuucucgauccccugaaugguggugcauggccgcuuuuggucgg
uggagugauuuguuugguugauuccgucaacggacgagauccaagcugcc
caguaggugccgggauuguccacacaggacagcaguccucgucauccuuc
uuuuuucaggccccuucucugcgggauuccuugcuuuucgcgcaagguga
gauuuugggcaacagcaggucugugaugcuccucaauguucugggcgaca
cgcgcacuacaaugucagugagaacaagagcgacgcucccgcuugaucaa
aagagcggggaaaccacggaaucacguagacccacuugggaccgaguauu
gcaauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaa
acugugccgauuacgucccugccauuuguacacaccgcccgucguuguuu
ccgaugauggugcaauacaggugaucggaccgucaccgaaaguucaccga
uauugcuucaauagaggaagcaaaagucguaacaagguagcuguagguga
accugcagcuggaucauuu
...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[
.[[[..<<....<<....<<<<...>>>>...>>.>>......{{.....
...[[[..[[..[[...[[..{......<<<<.>>>>....<<.....<<
<<<<.....>>>>>>......>>..........<<<<<.<<<<<<.>>.>
>>>>>>>>.[[((((((((.....<<<<<<<<<<<<<<<......>>>>>
.........................))))))))...]]....<<<<<<<.
>>>>>>>...}..]]..]]]]..]]].<<<....<<<....<<<<<.<<.
......>>.>>>>>>>>......>>>..<<<.<<<<....>>>>....>>
>.}}.<<.<<<..........>>>.>>.<<<<<..>>>>>...]]]]]].
........<<<....<<<..........>>>..>>>.......]]]....
<<<...<.<.....>.>...>>>.....<.<..............>....
..>.........<<<<<((....<.<<<<.....<<..))>>.......>
>>>>>>>>>..]]]]]]}}}}.........[[[[[.....((((...(((
.......<<<<...<...<..<<....<<..<.<...........>.>..
>>..>>.>...>..>>>>.................<...<<........<
...<<<.......>>>.>...>>...>...<<..<...........<...
<<.......>>..<......>.......>..........>....>>....
.......[[..(((.....>>>>>>>>>>....)))..]]........<<
<<<<<<<....<<<..>.>>.....>>>>>>>>>.............<<<
<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>
>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....)))
...))))...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>
>>>>.........<<<.<<...<..<.<<<<<..................
......<<<<.......>>>>.>>>>>.>..>......<<..]]>>....
.>>.....>>>.]]].<<<......<<<<....>>>>....>>>..}}}}
..<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<....
....>>..........<<<<<.<....<<<<<........<<.<<<....
....>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<
<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.
....<<<.<<<<<<................................>>>.
........>>>.>>>.....>>>>....<<<<<<<....>.>>>>>>...
....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.
>>>>>.>>.....<<<.<<<.......<...<....><<<<<<<......
..>>>>>>>....>........>>>...>>>......<....<<<.<<..
........>>.>>>.....>.....>>>>>>....<<<<<<<........
.>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<
<<..<<.<<<.<<<<<<..<<<<<.<...<.<<.>>.>...>.>>>>>..
>>>>>>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		R26 L116 K118 W119 R138 F140 Q148 N150 Q151 S153 K154 N155 Y157 T160 W165 R167 M168 R169 N204 P205 I206 K218
Binding residue
(residue number reindexed from 1)		R5 L93 K95 W96 R115 F117 Q125 N127 Q128 S130 K131 N132 Y134 T137 W142 R144 M145 R146 N181 P182 I183 K195
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ38BK6

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