Structure of PDB 9f6i Chain A Binding Site BS01

Receptor Information

>9f6i Chain A (length=1118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDK
RLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQG
KIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKK
NREQDDQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEI
TRRDDLVERPDPVVLAFAIATTKLPLKFPDAETDQIMMISYMIDGQGYLI
TNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPT
IMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDC
LRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLAT
YSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMV
QAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIP
CRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKL
ASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFN
KPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAF
HELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDT
VRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLA
HKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPL
ELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTN
DQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYA
VFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVA
KVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTA
KRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRK
HFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNP
VPRVKHPDWLHKKLLEKN

Ligand information

>9f6i Chain P (length=14) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tcgaatcctggatc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9f6i Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	V419 D862 K969 K974 R975 R976 S1040 Q1049
Binding residue (residue number reindexed from 1)	V362 D805 K912 K917 R918 R919 S983 Q992

External links

PDB	RCSB:9f6i, PDBe:9f6i, PDBj:9f6i
PDBsum	9f6i
PubMed	39112807
UniProt	Q07864\|DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (Gene Name=POLE)

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