Structure of PDB 9f6f Chain A Binding Site BS01

Receptor Information

>9f6f Chain A (length=1140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDK
RLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQG
KIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKK
NREQDDQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEI
TRRDDLVERPDPVVLAFAIATTKLPLKFPDAETDQIMMISYMIDGQGYLI
TNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPT
IMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDC
LRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLAT
YSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMV
QAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIP
CRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKL
ASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFN
KPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAF
HELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDT
VRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLA
HKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPL
ELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTN
DQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYA
VFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVA
KVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTA
KRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRK
HFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNP
VPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTM

Ligand information

>9f6f Chain P (length=24) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccttccacttcccaaccctcacca

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9f6f Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Resolution	3.75 Å
Binding residue (original residue number in PDB)	V419 D860 K969 K974 R975 R976 S1040
Binding residue (residue number reindexed from 1)	V362 D803 K912 K917 R918 R919 S983

External links

PDB	RCSB:9f6f, PDBe:9f6f, PDBj:9f6f
PDBsum	9f6f
PubMed	39112807
UniProt	Q07864\|DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (Gene Name=POLE)

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