Structure of PDB 9ca1 Chain A Binding Site BS01

Receptor Information

>9ca1 Chain A (length=612) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VMKTVLMVAEMPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQP
VRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMV
KFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFR
ARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKY
FQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNT
DKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPL
ALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFD
LKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEA
ELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLS
PGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAEL
ITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYY
KIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDS
IAGMDELMEVSF

Ligand information

>9ca1 Chain D (length=7) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tactaaa

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9ca1 Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics
Resolution	3.26 Å
Binding residue (original residue number in PDB)	H60 T63 N71 W73 R181 L186 G189 C190 R194 S213 F214 G215 Q218 Y336 T510 H517
Binding residue (residue number reindexed from 1)	H61 T64 N72 W74 R182 L187 G190 C191 R195 S214 F215 G216 Q219 Y337 T511 H518

External links

PDB	RCSB:9ca1, PDBe:9ca1, PDBj:9ca1
PDBsum	9ca1
PubMed
UniProt	O95985\|TOP3B_HUMAN DNA topoisomerase 3-beta-1 (Gene Name=TOP3B)

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