Structure of PDB 9ca0 Chain A Binding Site BS01

Receptor Information
>9ca0 Chain A (length=612) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VMKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQP
VRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMV
KFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFR
ARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKY
FQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNT
DKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPL
ALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFD
LKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEA
ELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLS
PGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAEL
ITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYY
KIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDS
IAGMDELMEVSF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9ca0 Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics
Resolution3.48 Å
Binding residue
(original residue number in PDB)		E9 H60 T63 N71 W73 R181 D185 L186 G189 C190 T193 R194 S213 F214 C217 Q218 Y336 T510 S513 H517 R524 R561
Binding residue
(residue number reindexed from 1)		E10 H61 T64 N72 W74 R182 D186 L187 G190 C191 T194 R195 S214 F215 C218 Q219 Y337 T511 S514 H518 R525 R562
External links
PDB RCSB:9ca0, PDBe:9ca0, PDBj:9ca0
PDBsum9ca0
PubMed
UniProtO95985|TOP3B_HUMAN DNA topoisomerase 3-beta-1 (Gene Name=TOP3B)

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