Structure of PDB 9c8u Chain A Binding Site BS01

Receptor Information
>9c8u Chain A (length=475) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHIL
TSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFM
VEDPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKCNYS
FHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKPNIE
PPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
IINHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRC
KAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKK
HLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYM
CSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFA
KRAIQTGEELFFDYRYSQADALKYV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain9c8u Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9c8u Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C528 H530 C535 C539
Binding residue
(residue number reindexed from 1)		C261 H263 C268 C272
Annotation score1
External links
PDB RCSB:9c8u, PDBe:9c8u, PDBj:9c8u
PDBsum9c8u
PubMed
UniProtQ15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (Gene Name=EZH2)

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