Structure of PDB 9bs4 Chain A Binding Site BS01

Receptor Information

>9bs4 Chain A (length=627) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAENSRPPPPLTASGVFSKFRDIARLTGSA
STAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVS
LTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIP
VLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYK
YDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPSVTSFIL
DTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGE
SLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDS
CEGLMVKTLDVDATYEIAKRSHNWLKLKKDYDTLDLVVIGAYLGRGKRAG
RYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPY
VRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFP
RFIRVREDKQPEQATTSAQVACLYRKQ

Ligand information

>9bs4 Chain B (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gctgatgcgtg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9bs4 Structures of LIG1 uncover the mechanism of sugar discrimination against 5'-RNA-DNA junctions during ribonucleotide excision repair.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	G348 V349 G350 G352 V353 G571 Q572 S588 R589 N590 F635
Binding residue (residue number reindexed from 1)	G87 V88 G89 G91 V92 G303 Q304 S320 R321 N322 F367

External links

PDB	RCSB:9bs4, PDBe:9bs4, PDBj:9bs4
PDBsum	9bs4
PubMed	39159820
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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