Structure of PDB 9awj Chain A Binding Site BS01

Receptor Information
>9awj Chain A (length=399) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEHETRLVAKLFEDYNSVVRPVEDHRQAVEVTVGLQLIQLINVDEVNQIV
TTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF
AIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWT
YDGSVVVINPESDQPDLSNFMESGEWVIKESRGWKHWVFYACCPSTPYLD
ITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVL
LSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH
RSPSTHVMPEWVRKVFIDTIPNIMFFSTMIKHPEVKSAIEGIKYIAETMK
SDQESNNAAEEWKYVAMVMDHILLAVFMLVCIIGTLAVFAGRLIELNQQ
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain9awj Chain H Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9awj Structural switch in acetylcholine receptors in developing muscle
Resolution2.45 Å
Binding residue
(original residue number in PDB)		H206 W207
Binding residue
(residue number reindexed from 1)		H186 W187
Annotation score1
Gene Ontology
Molecular Function
GO:0015464 acetylcholine receptor activity
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
GO:0042166 acetylcholine binding
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
GO:0003009 skeletal muscle contraction
GO:0007271 synaptic transmission, cholinergic
GO:0007274 neuromuscular synaptic transmission
GO:0007528 neuromuscular junction development
GO:0019228 neuronal action potential
GO:0034220 monoatomic ion transmembrane transport
GO:0035094 response to nicotine
GO:0042391 regulation of membrane potential
GO:0046716 muscle cell cellular homeostasis
GO:0048630 skeletal muscle tissue growth
GO:0050881 musculoskeletal movement
GO:0050905 neuromuscular process
GO:0051899 membrane depolarization
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0070050 neuron cellular homeostasis
GO:0095500 acetylcholine receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0031594 neuromuscular junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0099634 postsynaptic specialization membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9awj, PDBe:9awj, PDBj:9awj
PDBsum9awj
PubMed39085615
UniProtP02709|ACHA_BOVIN Acetylcholine receptor subunit alpha (Gene Name=CHRNA1)

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