Structure of PDB 8y85 Chain A Binding Site BS01

Receptor Information
>8y85 Chain A (length=514) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSP
AITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLL
VFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPF
TQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEPSPRNQPNTALLS
LILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSI
TDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLV
LILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWL
TAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSI
VMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPY
VTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLL
PRLFQDRELQALDS
Ligand information
Ligand IDBCT
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)(O)[O-]
CACTVS 3.341OC([O-])=O
ACDLabs 10.04[O-]C(=O)O
FormulaC H O3
NameBICARBONATE ION
ChEMBL
DrugBank
ZINC
PDB chain8y85 Chain A Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8y85 The structural insight into the functional modulation of human anion exchanger 3
Resolution2.73 Å
Binding residue
(original residue number in PDB)		A1049 V1051
Binding residue
(residue number reindexed from 1)		A353 V355
Annotation score5
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0022857 transmembrane transporter activity
GO:0140900 chloride:bicarbonate antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0015698 inorganic anion transport
GO:0015701 bicarbonate transport
GO:0034220 monoatomic ion transmembrane transport
GO:0045851 pH reduction
GO:0051453 regulation of intracellular pH
GO:0055085 transmembrane transport
GO:0061337 cardiac conduction
GO:0086001 cardiac muscle cell action potential
GO:0098656 monoatomic anion transmembrane transport
GO:0098660 inorganic ion transmembrane transport
GO:0098901 regulation of cardiac muscle cell action potential
GO:0150104 transport across blood-brain barrier
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8y85, PDBe:8y85, PDBj:8y85
PDBsum8y85
PubMed39033175
UniProtP48751|B3A3_HUMAN Anion exchange protein 3 (Gene Name=SLC4A3)

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