Structure of PDB 8y65 Chain A Binding Site BS01

Receptor Information
>8y65 Chain A (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDP
DTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAAL
LMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQ
VTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLP
DSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVS
VLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKI
PYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLT
LQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFII
AGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETK
NRTYAEISQAFSKRNKA
Ligand information
Ligand IDURC
InChIInChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
InChIKeyLEHOTFFKMJEONL-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC(=O)C2=C(N1)NC(=O)N2
OpenEye OEToolkits 1.5.0C12=C(NC(=O)N1)NC(=O)NC2=O
ACDLabs 10.04O=C1C2=C(NC(=O)N1)NC(=O)N2
FormulaC5 H4 N4 O3
NameURIC ACID;
7,9-DIHYDRO-1H-PURINE-2,6,8(3H)-TRIONE
ChEMBLCHEMBL792
DrugBankDB08844
ZINCZINC000002041003
PDB chain8y65 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8y65 Structural basis for urate recognition and apigenin inhibition of human GLUT9.
Resolution3.51 Å
Binding residue
(original residue number in PDB)		Y327 L332 N333 W336
Binding residue
(residue number reindexed from 1)		Y274 L279 N280 W283
Annotation score5
Gene Ontology
Molecular Function
GO:0005351 carbohydrate:proton symporter activity
GO:0005353 fructose transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015149 hexose transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0008645 hexose transmembrane transport
GO:0015747 urate transport
GO:0015749 monosaccharide transmembrane transport
GO:0015755 fructose transmembrane transport
GO:0046415 urate metabolic process
GO:1902600 proton transmembrane transport
GO:1904659 D-glucose transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8y65, PDBe:8y65, PDBj:8y65
PDBsum8y65
PubMed38866775
UniProtQ9NRM0|GTR9_HUMAN Solute carrier family 2, facilitated glucose transporter member 9 (Gene Name=SLC2A9)

[Back to BioLiP]