Structure of PDB 8xya Chain A Binding Site BS01

Receptor Information
>8xya Chain A (length=986) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSRSNSGVRLDGYARLVQQTILCHQNPVTGLLPASYDQKDAWVRDNVYSI
LAVWGLGLAYRKNADRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVES
FKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQMTAS
GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGISELNASS
VGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQSILNSLLPRAST
SKEVDASLLSVVSFPAFAVEDSQLVELTKQEIITKLQGRYGCCRFLRDGY
KTPKEDPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEY
KEALEAVLIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHM
WGQSLYILGSLMAEGFLAPGEIDPLNRRFSTVPKPDVVVQVSILAETEEI
KTILKDKGIYVETIAEVYPIRVQPARILSHIYSSLGCNNRMKLSGRPYRH
MGVLGTSKLYDIRKTIFTFTPQFIDQQQFYLALDNKMIVEMLRTDLSYLC
SRWRMTGQPTITFPISHSMLDEDGTSLNSSILAALRKMQDGYFGGARVQT
GKLSEFLTTSCCTHLSFMDPEVARYLDHLLAEQADILYMLYTMKGPDWNT
ELYNLLTELYGKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHL
TVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVYLAMY
MRTQPGLFAEMFRLRIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAM
KNLLHHILSGKEFQGQWQRRRRLDGALNRVPVGFYQKVWKVLQKCHGLSV
EGFVLPSSTTREMTPGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTML
ADIEIHSIGSIIAVEKIVHIANDLFLQEQKTLGADDTMLAKDPASGICTL
LYDSAPSGRFGTMTYLSKAAATYVQEFLPHSICAMQ
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain8xya Chain A Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xya Architecture and activation of human muscle phosphorylase kinase
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K1081 L1137 A1138 E1141 V1211 C1220
Binding residue
(residue number reindexed from 1)		K844 L900 A901 E904 V974 C983
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004689 phosphorylase kinase activity
GO:0005516 calmodulin binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0045819 positive regulation of glycogen catabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005964 phosphorylase kinase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8xya, PDBe:8xya, PDBj:8xya
PDBsum8xya
PubMed38548794
UniProtP46020|KPB1_HUMAN Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Gene Name=PHKA1)

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