Structure of PDB 8wxz Chain A Binding Site BS01

Receptor Information

>8wxz Chain A (length=1079) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MEWIHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPL
DVEQAFAFYVKTLTHSGKGIPHILQHSVLSGSKNYNYKNSIGLLEKGTLH
THLNAYTFNDRTVYMAGSMNNKDFFNIMGVYMDSVFQPNVLENKYIFETE
GWTYEVEKLKEDEKGKAEIPQMKDYKVSFNGIVYNEMKGALSSPLEDLYH
EEMKYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKKVKVFFFS
KNNPTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDH
SEEKENLVSVAWLLNPKVSLENPTDYFVLLIINNLLIHTPESVLYKALTD
CGLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHYEVEDVIM
NALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSKLNY
NRDPLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILLEGD
ENYAQEQENLEKQELKKRIENFNEQEKEQVIKNFEELSKYKNAEESPEHL
NKFPIISISDLNKKTLEVPVNVYFTNINENNNIMETYNKLKTNEHMLKDN
MDVFLKKYVLKDYSFTETKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTV
DELAYLNLFKTLILENKTNKRSSEDFVILREKNIGSMSANVALYSKDDHL
NVTDKYNAQALFNLEMHVLSHKCNDALNIALEAVKESDFSNKKKVIDILK
RKINGMKTTFSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQEQLE
LAENDFKTLENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKN
LVSYFEENDKYINMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGI
LFKPGEYLDPSFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFL
SARDPNLEKTLATFRESAKGLRKMADTMTENDLLRYIINTIGTIDKPRRG
IELSKLSFLRLISNESEQDRVEFRKRIMNTKKEDFYKFADLLESKVNEFE
KNIVIITTKEKANEYIANVDGEFKKVLIE

Ligand information

>8wxz Chain P (length=6) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

TQRFFE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8wxz Falcilysin in complex with hemoglobin alpha chain peptide
Resolution	2.3 Å
Binding residue (original residue number in PDB)	H129 Q132 H133 I148 L160 N161 A162 Y163 T164 E243 Y868 W1039 R1043 Y1049
Binding residue (residue number reindexed from 1)	H72 Q75 H76 I91 L103 N104 A105 Y106 T107 E186 Y765 W925 R929 Y935

External links

PDB	RCSB:8wxz, PDBe:8wxz, PDBj:8wxz
PDBsum	8wxz
PubMed
UniProt	Q76NL8\|FCLN_PLAF7 Falcilysin (Gene Name=FLN)

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