Structure of PDB 8wtw Chain A Binding Site BS01

Receptor Information

>8wtw Chain A (length=551) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLII
AGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNV
IIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKYSKYKFTPAAEFYER
GVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWIT
ATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIF
FSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILG
YMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALG
LDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGI
YVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLY
WRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSM
VLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLA
I

Ligand information

>8wtw Chain B (length=13) Species: 42752 (Conus marmoreus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YRGLCCGKLCRPC

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8wtw Transport and inhibition mechanisms of the human noradrenaline transporter.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	W80 R81 D310 D473 K541 P542 T544
Binding residue (residue number reindexed from 1)	W26 R27 D244 D407 K475 P476 T478

External links

PDB	RCSB:8wtw, PDBe:8wtw, PDBj:8wtw
PDBsum	8wtw
PubMed	39085602
UniProt	P23975\|SC6A2_HUMAN Sodium-dependent noradrenaline transporter (Gene Name=SLC6A2)

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