Structure of PDB 8wp1 Chain A Binding Site BS01

Receptor Information
>8wp1 Chain A (length=304) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSS
NIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYT
SILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPIL
PLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYY
KIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIAS
RLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMN
QLRH
Ligand information
Ligand IDU9S
InChIInChI=1S/C4H4O5/c5-3(6)1-2(9-1)4(7)8/h1-2H,(H,5,6)(H,7,8)/t1-,2+
InChIKeyDCEMCPAKSGRHCN-XIXRPRMCSA-N
SMILES
SoftwareSMILES
CACTVS 3.385OC(=O)[CH]1O[CH]1C(O)=O
OpenEye OEToolkits 2.0.7[C@@H]1([C@H](O1)C(=O)O)C(=O)O
CACTVS 3.385OC(=O)[C@H]1O[C@H]1C(O)=O
ACDLabs 12.01C(C1C(O1)C(O)=O)(=O)O
OpenEye OEToolkits 2.0.7C1(C(O1)C(=O)O)C(=O)O
FormulaC4 H4 O5
Name(2R,3S)-oxirane-2,3-dicarboxylic acid;
cis-2,3-epoxysuccinic acid
ChEMBLCHEMBL1741775
DrugBank
ZINCZINC000001675960
PDB chain8wp1 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8wp1 Structural insights into ligand recognition and activation of the succinate receptor SUCNR1.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		Y83 R99 L102 D174 R281
Binding residue
(residue number reindexed from 1)		Y75 R91 L94 D166 R273
Annotation score1
External links
PDB RCSB:8wp1, PDBe:8wp1, PDBj:8wp1
PDBsum8wp1
PubMed38923454
UniProtQ9BXA5|SUCR1_HUMAN Succinate receptor 1 (Gene Name=SUCNR1)

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