Structure of PDB 8wox Chain A Binding Site BS01

Receptor Information
>8wox Chain A (length=588) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STIEELAKTFLEKFNQEAEDLSYQSALASWDYNTNITEENVQKMNDAEAK
WSAFYEEQSKLAKTYPSQEVQNLTVKRQLQALQQSGSSALSADKSKQLNT
ILSTMSTIYSTGKVCFLLEPGLDEIMAKSTDYNERLWAWEGWRSVVGKQL
RPLYEEYVVLKNEMARANNYEDYGDYWRADYEAEGADGYDYSRSQLIDDV
ERTFSEIKPLYEQLHAFVRTKLMDAYPSRISPTGCLPAHLLGDMWGRFWT
NLYSLTVPFGQKPNIDVTDTMVNQGWDAERIFKEAEKFFVSVGLPSMTQG
FWENSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMDNFLTAHHEM
GHIQYDMAYATQPFLLRNGANEGFHEAVGEIMSLSAATPEHLKSIGLLPY
DFHEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKEQWMQK
WWEMKREIVGVVEPMPHDETYCDPAALFHVANDYSFIRYYTRTIYQFQFQ
EALCQAAQHEGPLHKCDISNSTEAGQKLLNMLRLGRSEPWTLALENVVGA
KNMDVRPLLNYFEPLFTWLKEQNRNSFVGWSTEWTPYA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8wox Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8wox Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit-hare ACE2s reveals the expanding host tendency
Resolution2.75 Å
Binding residue
(original residue number in PDB)		H374 H378 E402
Binding residue
(residue number reindexed from 1)		H348 H352 E376
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.-.-
3.4.17.23: angiotensin-converting enzyme 2.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wox, PDBe:8wox, PDBj:8wox
PDBsum8wox
PubMed38112468
UniProtG1TEF4

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