Structure of PDB 8wky Chain A Binding Site BS01

Receptor Information
>8wky Chain A (length=468) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLFVSPVVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADML
VSVSLGFETIVITLLNSTDAQSFTVNIDNVIDSVICASLLASICSLLSIA
VDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVI
ICLITMFFTMLALMASLYVHMFLMARLHGIDCSFWNESYLTGSRDERKKS
LLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIII
GKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFE
PFGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILK
ALELSRSDLSKFRENCKKRAMSFSRQGANMKGAITLTILIGVFVVCWAPF
FLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIINPLIYALRSQELRK
TFKEIICCYEFLEVLFQG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8wky Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E100 I104 D122 D126 I129 C130 I185 S188 F261 H264 L265 Y268 F284 L288
Binding residue
(residue number reindexed from 1)		E58 I62 D78 D82 I85 C86 I141 S144 F400 H403 L404 Y407 F423 L427
External links
PDB RCSB:8wky, PDBe:8wky, PDBj:8wky
PDBsum8wky
PubMed38345933
UniProtP32245|MC4R_HUMAN Melanocortin receptor 4 (Gene Name=MC4R)

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