Structure of PDB 8wil Chain A Binding Site BS01

Receptor Information
>8wil Chain A (length=574) Species: 1491393 (Jingmen tick virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERITPEWTAEAVIEGCAPLTPLNMTRSIAEMHMEYPPLGITRFFKELGYK
IAKKKRKNRFVGQLIEPLRRVLERHHLFGATSTTPRAVFNMFRSKVDRAP
VELHSHYPGLKKMYDILADLWLERYGSMKRLTEEEMASAINRRGAMGYQM
DNRNYGDLGAYWDSGDWRQDVNTFKRALLSGTPTHAVYNTTAKRIIQYLP
ADARLYELKVLGGLHKYLEKCGWSVAGQGLYKYGDRVKKSMDATGAAISE
DVAGWDTKISKGLLTLESHMFTKLAEDEEMAREIHHLYRLYADPHMVVQR
EIEGEVHDVLLRGRGQVSSGRQPTYAANTITNFITTTYGMAVTLGIPEAD
WPRLIRDLTDERGNRRLLVSGDDKVLFLRGDEARVYASSAYRISNDMGLV
RKDMALEQESEIIVDVKEISFCSHRYWPVKYGNEIHYMPVRDVGEIFAKA
TMADMTQEAWARVQGLNMLVNYHHIPECRMLALAILSVTRIGLNLKGIST
EWLRDDLAPDTIHALITEGRTSGWDQLGYVDFKDRKGILLRPDTNYKNWR
RDLPEKVRQLREDGQYKDWLQKMA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8wil Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8wil A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D698 K699
Binding residue
(residue number reindexed from 1)		D373 K374
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016787 hydrolase activity
GO:0017111 ribonucleoside triphosphate phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0039694 viral RNA genome replication
Cellular Component
GO:0016020 membrane
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wil, PDBe:8wil, PDBj:8wil
PDBsum8wil
PubMed38296832
UniProtA0A7D0QVD8

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