Structure of PDB 8wi5 Chain A Binding Site BS01

Receptor Information
>8wi5 Chain A (length=1218) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSKHQHPVDNAGLFSCMTFSWLSSLARVAHGELSMEDVWSLSKHESSDVN
CRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFS
GPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYR
TGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGS
LLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRR
KCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKA
GYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTF
ALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNA
TLAWDSRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLE
GSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPD
LAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALD
AHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGT
HEELMNLNGDYATIFNNLLLSVPWSVYGVYIQAAGGPLAFLVIMALFMLN
VGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYA
LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTG
RILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVG
PLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNK
GQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVL
MHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKT
LSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKP
KEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSK
LSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKL
ESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQ
ETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS
SRFYAMFAAAENKVAVKG
Ligand information
>8wi5 Chain B (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CQDALETAARAEGLSLDASMHSQL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8wi5 Inhibition and transport mechanisms of the ABC transporter hMRP5.
Resolution3.46 Å
Binding residue
(original residue number in PDB)		Y244 I277 N282 R286 S337 T402 P451 F452 K455 V984 F988 M992 L1051 M1095 R1096 Q1144 R1148
Binding residue
(residue number reindexed from 1)		Y149 I182 N187 R191 S242 T307 P356 F357 K360 V765 F769 M773 L832 M876 R877 Q925 R929
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008514 organic anion transmembrane transporter activity
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015216 purine nucleotide transmembrane transporter activity
GO:0015232 heme transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0022884 macromolecule transmembrane transporter activity
GO:0034634 glutathione transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity
GO:0140359 ABC-type transporter activity
GO:1901505 carbohydrate derivative transmembrane transporter activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0006855 xenobiotic transmembrane transport
GO:0015865 purine nucleotide transport
GO:0030213 hyaluronan biosynthetic process
GO:0034775 glutathione transmembrane transport
GO:0035351 heme transmembrane transport
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
GO:0070730 cAMP transport
GO:0070731 cGMP transport
GO:0098656 monoatomic anion transmembrane transport
GO:0098838 folate transmembrane transport
GO:0140115 export across plasma membrane
GO:0150104 transport across blood-brain barrier
Cellular Component
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wi5, PDBe:8wi5, PDBj:8wi5
PDBsum8wi5
PubMed38844452
UniProtO15440|MRP5_HUMAN ATP-binding cassette sub-family C member 5 (Gene Name=ABCC5)

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