Structure of PDB 8wfi Chain A Binding Site BS01

Receptor Information
>8wfi Chain A (length=542) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNAGGAFMFPYFIMLIFC
GIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVV
ICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLRTSPSEEYWRLYVLKL
SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVV
LTILFVRGVTLEGAFDGIMYYLTPQWDKILAAKVWGDAASQIFYSLGCAW
GGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLG
VDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCL
LETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL
MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICW
RFVSPAIIFFILVFTVIQYPITAYNHYQYPGWAVAIGFLMALSSVLCIPL
YAMFRLCRTDGADLLQRLKNATKPSRDWGPALLEHRTGRYAP
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain8wfi Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8wfi Transport mechanism and pharmacology of the human GlyT1.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		A63 G65 G67 S317
Binding residue
(residue number reindexed from 1)		A18 G20 G22 S245
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
Biological Process
GO:0006836 neurotransmitter transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wfi, PDBe:8wfi, PDBj:8wfi
PDBsum8wfi
PubMed38513663
UniProtP48067|SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (Gene Name=SLC6A9)

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