Structure of PDB 8wa5 Chain A Binding Site BS01

Receptor Information
>8wa5 Chain A (length=987) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTP
EYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALI
AVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVV
GDLVEMKGGDRVPADIRILQAQGCKVDNSSLTGESEPQTRSPECTHESPL
ETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIE
IEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLL
ATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMT
VSHLWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQ
DAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNK
FQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREA
FQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLCFAG
LVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEG
SETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPE
MVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIA
GSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPEL
TPWLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPR
NPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLR
PQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIQMCQIADVLIR
KTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQ
WWLVPMPFSLLIFVYDEIRKLGVRCCPGSWWDQELYY
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain8wa5 Chain A Residue 1104 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8wa5 Specific protonation of acidic residues confers K+ selectivity to the gastric proton pump.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		T228 G229 D385 T387 K707 N729 D730
Binding residue
(residue number reindexed from 1)		T182 G183 D339 T341 K661 N683 D684
Annotation score1
Enzymatic activity
Enzyme Commision number 7.2.2.19: H(+)/K(+)-exchanging ATPase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0008900 P-type potassium:proton transporter activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005889 potassium:proton exchanging ATPase complex
GO:0016020 membrane
GO:0016324 apical plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8wa5, PDBe:8wa5, PDBj:8wa5
PDBsum8wa5
PubMed38072058
UniProtP19156|ATP4A_PIG Potassium-transporting ATPase alpha chain 1 (Gene Name=ATP4A)

[Back to BioLiP]