Structure of PDB 8w6n Chain A Binding Site BS01

Receptor Information
>8w6n Chain A (length=494) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEAL
PLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWN
LHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEA
VVQQIINAEAKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNT
RYPDCRCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGTVQQKACAEVIK
QEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPGFAT
DSTVALLIGLLFFLIPAKTLFDYSPLITWKEFQSFMPWDIAILVGGGFAL
ADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATIT
LFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHL
KVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWAPAM
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain8w6n Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8w6n Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S135 N140 G252 G258 T259
Binding residue
(residue number reindexed from 1)		S132 N137 G181 G187 T188
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0015373 monoatomic anion:sodium symporter activity
GO:0015382 sodium:sulfate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0098656 monoatomic anion transmembrane transport
GO:1902358 sulfate transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w6n, PDBe:8w6n, PDBj:8w6n
PDBsum8w6n
PubMed38552027
UniProtQ9BZW2|S13A1_HUMAN Solute carrier family 13 member 1 (Gene Name=SLC13A1)

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