Structure of PDB 8w2o Chain A Binding Site BS01

Receptor Information
>8w2o Chain A (length=169) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVSRLFKPRPPLSYKRPTDYPYAKRQTNPNITGVANLLSTSLKHYMEEFP
EGSPNNHLQRYEDIKLSKIKNAQLLDRRLHIKDTDPYRTIFIGRLPYDLD
EIELQKYFVKFGEIEKIRIVKDKITQKSKGYAFIVFKDPISSKMAFKEIG
VHRGIQIKDRICIVDIERG
Ligand information
>8w2o Chain R (length=327) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accuuaagauaucagaggaaaguccuacugaucaaacaugcgcuuccaau
aguagaaggacguuaagcauuuaucauugaacuguucauugaagucauug
augcaaacuccuuggucacacacacauacggcgcggaaggcguguuugcu
gacguuuccauucccuuguuucaaucauugguuaaacugauuuuuggggc
ccuuuguuucuucugccuggagaaguuugacaccaaauucaaauuggugu
uaggggagcuggggccuuucaaaaaaauuuuggaaggucuugguaggaac
ggguggaucuuauaauuuuugauuuau
.....<<<<.<<<<<<<<.....>>>.>>>>><<<<<<<<<.<<<<<...
.....<<<<<.<<<..<<<<.<.<<<.<<<<<.>>>>>.>>>.......>
>>>>.>>>>>>>>.....................>>>>>>>>>>>>>><<
<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.>>>>>>>..>>>>>>>
((.......<<<<<....))>>>>>...<<<<<<<<.<....>>>>>>>>
>.>>>>><<<<<<<<<<<<<<<<<...>>>>>>>>>>>>>>>>>.>>>>>
>..>>>.>>>>................
Receptor-Ligand Complex Structure
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PDB8w2o Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast.
Resolution3.49 Å
Binding residue
(original residue number in PDB)		Y30 K34 R35 Q36 T37 N38 P39 N40 N81
Binding residue
(residue number reindexed from 1)		Y20 K24 R25 Q26 T27 N28 P29 N30 N71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0030619 U1 snRNA binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w2o, PDBe:8w2o, PDBj:8w2o
PDBsum8w2o
PubMed38688558
UniProtQ00916|RU17_YEAST U1 small nuclear ribonucleoprotein 70 kDa homolog (Gene Name=SNP1)

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