Structure of PDB 8vzo Chain A Binding Site BS01

Receptor Information
>8vzo Chain A (length=416) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVIKVSKRRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDW
LSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWVKLGSLEPH
LFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLG
IAIGFLVPPVLVPNIKDPEKLAYHISIMFYIIGGVATFLFILVIIVFKEK
PKHPPSRAQSLSYASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLL
NRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVV
YIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTY
PESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGS
ALTAFIKSDLRRQRAN
Ligand information
Ligand IDCHT
InChIInChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1
InChIKeyOEYIOHPDSNJKLS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		C[N+](C)(C)CCO
ACDLabs 10.04OCC[N+](C)(C)C
FormulaC5 H14 N O
NameCHOLINE ION
ChEMBLCHEMBL920
DrugBankDB00122
ZINCZINC000003079337
PDB chain8vzo Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8vzo Structural and molecular basis of choline uptake into the brain by FLVCR2
Resolution2.49 Å
Binding residue
(original residue number in PDB)		N121 A122 W125 Q214 L218 N245
Binding residue
(residue number reindexed from 1)		N23 A24 W27 Q116 L120 N147
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015220 choline transmembrane transporter activity
GO:0015232 heme transmembrane transporter activity
GO:0020037 heme binding
GO:0022857 transmembrane transporter activity
GO:0034228 ethanolamine transmembrane transporter activity
Biological Process
GO:0001701 in utero embryonic development
GO:0002040 sprouting angiogenesis
GO:0007420 brain development
GO:0010467 gene expression
GO:0015871 choline transport
GO:0015886 heme transport
GO:0034229 ethanolamine transport
GO:0055085 transmembrane transport
GO:0097102 endothelial tip cell fate specification
GO:0150104 transport across blood-brain barrier
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8vzo, PDBe:8vzo, PDBj:8vzo
PDBsum8vzo
PubMed38693257
UniProtQ91X85|FLVC2_MOUSE Heme transporter FLVCR2 (Gene Name=Flvcr2)

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