Structure of PDB 8vzn Chain A Binding Site BS01

Receptor Information
>8vzn Chain A (length=417) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIKVSKRRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWL
SMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWVKLGSLEPHL
FPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGI
AIGFLVPPVLVPNIKDPEKLAYHISIMFYIIGGVATFLFILVIIVFKEKP
KHPPSRAQSLSYASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN
RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVY
IMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYP
ESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSA
LTAFIKSDLRRQRANKD
Ligand information
Ligand IDCHT
InChIInChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1
InChIKeyOEYIOHPDSNJKLS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		C[N+](C)(C)CCO
ACDLabs 10.04OCC[N+](C)(C)C
FormulaC5 H14 N O
NameCHOLINE ION
ChEMBLCHEMBL920
DrugBankDB00122
ZINCZINC000003079337
PDB chain8vzn Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8vzn Structural and molecular basis of choline uptake into the brain by FLVCR2
Resolution2.77 Å
Binding residue
(original residue number in PDB)		W125 Q214 N245 I249 Y348
Binding residue
(residue number reindexed from 1)		W26 Q115 N146 I150 Y243
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015220 choline transmembrane transporter activity
GO:0015232 heme transmembrane transporter activity
GO:0020037 heme binding
GO:0022857 transmembrane transporter activity
GO:0034228 ethanolamine transmembrane transporter activity
Biological Process
GO:0001701 in utero embryonic development
GO:0002040 sprouting angiogenesis
GO:0007420 brain development
GO:0010467 gene expression
GO:0015871 choline transport
GO:0015886 heme transport
GO:0034229 ethanolamine transport
GO:0055085 transmembrane transport
GO:0097102 endothelial tip cell fate specification
GO:0150104 transport across blood-brain barrier
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0031966 mitochondrial membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8vzn, PDBe:8vzn, PDBj:8vzn
PDBsum8vzn
PubMed38693257
UniProtQ91X85|FLVC2_MOUSE Heme transporter FLVCR2 (Gene Name=Flvcr2)

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