Structure of PDB 8vzm Chain A Binding Site BS01

Receptor Information

>8vzm Chain A (length=646) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRD
IARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVL
AALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEV
PDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE
AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKL
PSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEF
LEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLV
VIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQ
SLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARG
LVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQ

Ligand information

>8vzm Chain B (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gctgatgcgta

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8vzm Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA.
Resolution	2.51 Å
Binding residue (original residue number in PDB)	G348 G350 G571 Q572 R573 S588 R589 N590 N594 F635 R643 R871 F872
Binding residue (residue number reindexed from 1)	G88 G90 G311 Q312 R313 S328 R329 N330 N334 F375 R383 R611 F612

Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

External links

PDB	RCSB:8vzm, PDBe:8vzm, PDBj:8vzm
PDBsum	8vzm
PubMed	38522520
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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