Structure of PDB 8vzl Chain A Binding Site BS01

Receptor Information
>8vzl Chain A (length=646) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRD
IARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVL
AALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEV
PDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE
AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKL
PSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEF
LEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLV
VIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQ
SLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARG
LVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8vzl Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA.
Resolution2.41 Å
Binding residue
(original residue number in PDB)		G348 G350 G571 Q572 S588 R589 A592 N594 F635 R871 F872
Binding residue
(residue number reindexed from 1)		G88 G90 G311 Q312 S328 R329 A332 N334 F375 R611 F612
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
External links
PDB RCSB:8vzl, PDBe:8vzl, PDBj:8vzl
PDBsum8vzl
PubMed38522520
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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