Structure of PDB 8vv3 Chain A Binding Site BS01

Receptor Information
>8vv3 Chain A (length=387) Species: 7091 (Bombyx mori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPCLVGGAHAFILKISSFCGLAPLRFEPRSQEYAVTISKGKCFYSYILVT
FLVICTIYGLVAEIGVGVEKSVRMSSRMSQVVSACDILVVAVTAGVGVYG
APARMRTMLSYMENIVAVDRELGRHHSAATERKLCALLLLILLSFTILLV
DDFCFYAMQAGKTGRQWEIVTNYAGFYFLWYIVMVLELQFAFTALSLRAR
LKLFNEALNVTASQVCAFVMMKPCLQVPPCEAVGRLSRMRCTLCEVTRHI
ADGYGLPLVIILMSTLLHLIVTPYFLIMEIIVSTHRLHFLVLQFLWCTTH
LIRMLVVVEPCHYTIREGKRTEDILCRLMTLAPHGGVLSSRLEVLSRLLM
LQNISYSPLGMCTLDRPLMVTVLGAVTTYLVILIQFQ
Ligand information
Ligand IDSOE
InChIInChI=1S/C6H12O6/c7-2-6(11)5(10)4(9)3(8)1-12-6/h3-5,7-11H,1-2H2/t3-,4+,5-,6+/m0/s1
InChIKeyLKDRXBCSQODPBY-BGPJRJDNSA-N
SMILES
SoftwareSMILES
CACTVS 3.370OC[C]1(O)OC[CH](O)[CH](O)[CH]1O
ACDLabs 12.01OC1C(O)(OCC(O)C1O)CO
CACTVS 3.370OC[C@@]1(O)OC[C@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.7.0C1C(C(C(C(O1)(CO)O)O)O)O
OpenEye OEToolkits 1.7.0C1[C@@H]([C@H]([C@@H]([C@](O1)(CO)O)O)O)O
FormulaC6 H12 O6
Namealpha-L-sorbopyranose;
alpha-L-sorbose;
L-sorbose;
sorbose;
L-sorbose in pyranose form
ChEMBL
DrugBank
ZINCZINC000003861737
PDB chain8vv3 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8vv3 The molecular basis of sugar detection by an insect taste receptor.
Resolution2.61 Å
Binding residue
(original residue number in PDB)		R86 D99 D165 Y190 W193 T330 Q351 W354 H358
Binding residue
(residue number reindexed from 1)		R73 D86 D152 Y177 W180 T272 Q293 W296 H300
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0170021 ionotropic taste receptor activity
Biological Process
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007165 signal transduction
GO:0007635 chemosensory behavior
GO:0008049 male courtship behavior
GO:0050909 sensory perception of taste
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8vv3, PDBe:8vv3, PDBj:8vv3
PDBsum8vv3
PubMed38447670
UniProtB3GTD7

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