Structure of PDB 8vkz Chain A Binding Site BS01
Receptor Information
>8vkz Chain A (length=240) Species:
9606
(Homo sapiens) [
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TPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQMIAAVKWA
KAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLI
INEQRPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLK
SQELFDEIRMTYIKELGKAIVSQNWQRFYQLTKLLDSMHEVVENLLNYCF
QTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
Ligand information
>8vkz Chain D (length=9) Species:
9606
(Homo sapiens) [
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NALLRYLLD
Receptor-Ligand Complex Structure
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PDB
8vkz
Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties
Resolution
2.133 Å
Binding residue
(original residue number in PDB)
I572 V575 K579 R585 M593 Q597 M752 E755
Binding residue
(residue number reindexed from 1)
I44 V47 K51 R57 M65 Q69 M215 E218
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:8vkz
,
PDBe:8vkz
,
PDBj:8vkz
PDBsum
8vkz
PubMed
38516584
UniProt
P04150
|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)
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