Structure of PDB 8vjx Chain A Binding Site BS01

Receptor Information

>8vjx Chain A (length=665) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYEN
CLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMS
MRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNE
IKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDD
KYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLR
TKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFI
LNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIE
VVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYL
DLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPSLL
RHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVW
DVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQS
LHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYL
WSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLK
REPNQKAFLMSRGLH

Ligand information

>8vjx Chain C (length=6) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PGFSPF

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8vjx Structural basis of divergent substrate recognition and inhibition of human neurolysin.
Resolution	2.89 Å
Binding residue (original residue number in PDB)	Y222 F226 Y339 H425 C428 T471 H474 E475 H478 E510 R554 H601 Y610 Y613
Binding residue (residue number reindexed from 1)	Y208 F212 Y325 H411 C414 T457 H460 E461 H464 E496 R540 H587 Y596 Y599

External links

PDB	RCSB:8vjx, PDBe:8vjx, PDBj:8vjx
PDBsum	8vjx
PubMed	39117724
UniProt	Q9BYT8\|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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