Structure of PDB 8vjv Chain A Binding Site BS01

Receptor Information

>8vjv Chain A (length=665) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYEN
CLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMS
MRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNE
IKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDD
KYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLR
TKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFI
LNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIE
VVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYL
DLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPSLL
RHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVW
DVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQS
LHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYL
WSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLK
REPNQKAFLMSRGLH

Ligand information

>8vjv Chain D (length=6) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YGGFRR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8vjv Structural basis of divergent substrate recognition and inhibition of human neurolysin.
Resolution	2.12 Å
Binding residue (original residue number in PDB)	N180 Y423 H425 A426 A427 C428 T471 H474 E475 H478 R554 Q555 L558 T598 H601 Y610 Y613
Binding residue (residue number reindexed from 1)	N166 Y409 H411 A412 A413 C414 T457 H460 E461 H464 R540 Q541 L544 T584 H587 Y596 Y599

External links

PDB	RCSB:8vjv, PDBe:8vjv, PDBj:8vjv
PDBsum	8vjv
PubMed	39117724
UniProt	Q9BYT8\|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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