Structure of PDB 8vju Chain A Binding Site BS01

Receptor Information

>8vju Chain A (length=665) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYEN
CLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMS
MRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNE
IKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDD
KYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLR
TKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFI
LNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIE
VVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYL
DLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPSLL
RHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVW
DVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQS
LHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYL
WSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLK
REPNQKAFLMSRGLH

Ligand information

>8vju Chain C (length=6) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

FLRRIR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8vju Structural basis of divergent substrate recognition and inhibition of human neurolysin.
Resolution	1.99 Å
Binding residue (original residue number in PDB)	N180 Y423 H425 A427 C428 F429 T471 H474 E475 E510 R554 G600 H601 Y606 Y610 Y613
Binding residue (residue number reindexed from 1)	N166 Y409 H411 A413 C414 F415 T457 H460 E461 E496 R540 G586 H587 Y592 Y596 Y599

External links

PDB	RCSB:8vju, PDBe:8vju, PDBj:8vju
PDBsum	8vju
PubMed	39117724
UniProt	Q9BYT8\|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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