Structure of PDB 8v9q Chain A Binding Site BS01

Receptor Information
>8v9q Chain A (length=500) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEG
CKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVD
DASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSRGQVI
TFLDAHCECTAGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMT
YGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQE
IGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFP
GGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRLGLRRK
LQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVG
IFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQL
WEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCTGSRSQQWLLRNVTL
Ligand information
Receptor-Ligand Complex Structure
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PDB8v9q An unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		V240 W267 F346 R347 A349 T350 E450 K496 N503 N519
Binding residue
(residue number reindexed from 1)		V185 W212 F291 R292 A294 T295 E395 K441 N448 N464
Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v9q, PDBe:8v9q, PDBj:8v9q
PDBsum8v9q
PubMed38416819
UniProtO08912|GALT1_MOUSE Polypeptide N-acetylgalactosaminyltransferase 1 (Gene Name=Galnt1)

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