Structure of PDB 8v24 Chain A Binding Site BS01

Receptor Information

>8v24 Chain A (length=327) Species: 199310 (Escherichia coli CFT073) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KEDTGTVEAHLTLGNLFRSRGEVDRAIRIHQTLMESASLTYEQRLLAIQQ
LGRDYMAAGLYDRAEDMFNQLTDETDFRIGALQQLLQIYQATSEWQKAID
VAERLVKLGKDKQRVEIAHFYCELALQHMASDDLDRAMTLLKKGAAADKN
SARVSIMMGRVFMAKGEYAKAVESLQRVISQDRELVSETLEMLQTCYQQL
GKTAEWAEFLQRAVEENTGADAELMLADIIEARDGSEAAQVYITRQLQRH
PTMRVFHKLMDYHLNEAEEGRAKESLMVLRDMVGEKVRSKPRYRCQKCGF
TAYTLYWHCPSCRAWSTIKPIRGLDGL

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8v24 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8v24 Dual function of LapB (YciM) in regulating Escherichia coli lipopolysaccharide synthesis.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	C357 C371 C374
Binding residue (residue number reindexed from 1)	C295 C309 C312
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0008653	lipopolysaccharide metabolic process
GO:0046890	regulation of lipid biosynthetic process

	Cellular Component
GO:0005886	plasma membrane
GO:0009898	cytoplasmic side of plasma membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8v24, PDBe:8v24, PDBj:8v24
PDBsum	8v24
PubMed	38635633
UniProt	P0AB59\|LAPB_ECOL6 Lipopolysaccharide assembly protein B (Gene Name=lapB)

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