Structure of PDB 8uw3 Chain A Binding Site BS01

Receptor Information
>8uw3 Chain A (length=1265) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLK
IKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQ
QEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSTLDR
STRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFFSAPHHTYSKID
HIVGSKALLSKCKRTEIITNYLSDHSAIKLELRIKNSTTWKLNNLLLNDY
WVHNEMKAEIKMFFETNENKDTTYQNLWDAFKAVCRGKFIALNAHKRKQE
RSKIDTLTSQLKELEKQEQTHSKASRRQEITKIRAELKEIETQKTLQKIN
ESRSWFFERINKIDRPLARLIKKKREKNQIDTIKNDKGDITTDPTEIQTT
IREYYKHLYANKLENLEEMDKFLDTYTLPRLNQEEVESLNRPITGSEIVA
IINSLPTKKSPGPDGFTAEFYQRYKEELVPFLLKLFQSIEKEGILPNSFY
EASIILIPKPGRDTTKKENFRPISLMNIDAKILNKILANRIQQHIKKLIH
HDQVGFIPGMQGWFNIRKSINVIQHINRAKDKNHMIISIDAEKAFDKIQQ
PFMLKTLNKLGIDGTYFKIIRAIYDKPTANIILNGQKLEAFPLKTGTRQG
CPLSPLLFNIVLEVLARAIRQEKEIKGIQLGKEEVKLSLFADDMIVYLEN
PIVSAQNLLKLISNFSKVSGYKINVQKSQAFLYTNNRQTESQIMGELPFT
IASKRIKYLGIQLTRDVKDLFKENYKPLLKEIKEETNKWKNIPCSWVGRI
NIVKMAILPKVIYRFNAIPIKLPMTFFTELEKTTLKFIWNQKRARIAKSI
LSQKNKAGGITLPDFKLYYKATVTKTAWYWYQNRDIDQWNRTEPSEIMPH
IYNYLIFDKPEKNKQWGKDSLFNKWCWENWLAICRKLKLDPFLTPYTKIN
SRWIKDLNVKPKTIKTLEENLGITIQDIGVGKDFMSKTPKAMATKDKIDK
WDLIKLKSFCTAKETTIRVNRQPTTWEKIFATYSSDKGLISRIYNELKQI
YKKKTNNPIKKWAKDMNRHFSKEDIYAAKKHMKKCSSSLAIREMQIKTTM
RYHLTPVRMAIIKKSGNNRCWRGCGEIGTLLHCWWDCKLVQPLWKSVWRF
LRDLELEIPFDPAIPLLGIYPNEYKSCCYKDTCTRMFIAALFTIAKTWNQ
PKCPTMIDWIKKMWHIYTMEYYAAIKNDEFISFVGTWMKLETIILSKLSQ
EQKTKHRIFSLIGGN
Ligand information
>8uw3 Chain B (length=63) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcagacugcguaggcgugcgcacgccuacgcagucugcaaaaaaaaaaaa
aaacaauaucggc
..<<<<<<<<<<<<<<<<..>>>>>>>>>>>>>>>>..............
.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uw3 Template and target site recognition by human LINE-1 in retrotransposition
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H52 S362 R363 W365 F366 I370 R375 P376 L377 R379 L380 R385 K468 K469 S470 I515 I517 I533 L535 K541 K545 F566 Q659 G660 C661 P662 P665 P803 C804 M834 R853 A857 K858 N865 T871 Y878 K928 E938 K1047 G1048 I1050 S1051 K1063 K1071 K1107 H1113 L1114 R1118 M1119 I1121 I1122 K1123 W1131 F1202 A1205 K1206 W1208 N1209 Q1210 K1236
Binding residue
(residue number reindexed from 1)		H47 S352 R353 W355 F356 I360 R365 P366 L367 R369 L370 R375 K458 K459 S460 I505 I507 I523 L525 K531 K535 F556 Q649 G650 C651 P652 P655 P793 C794 M824 R843 A847 K848 N855 T861 Y868 K918 E928 K1037 G1038 I1040 S1041 K1053 K1061 K1097 H1103 L1104 R1108 M1109 I1111 I1112 K1113 W1121 F1192 A1195 K1196 W1198 N1199 Q1200 K1226
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003964 RNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006310 DNA recombination
GO:0032197 retrotransposition
GO:0090304 nucleic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8uw3, PDBe:8uw3, PDBj:8uw3
PDBsum8uw3
PubMed38096901
UniProtO00370|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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