Structure of PDB 8uw1 Chain A Binding Site BS01

Receptor Information
>8uw1 Chain A (length=96) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAV
MALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Ligand information
>8uw1 Chain I (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcgagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacggattctcccccgcgttttaaccgccaaggg
gattactccctagtctccaggcacgtgtcagatatatacatccgat
Receptor-Ligand Complex Structure
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PDB8uw1 Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Resolution2.88 Å
Binding residue
(original residue number in PDB)		R40 Y41 G44 L65 R69
Binding residue
(residue number reindexed from 1)		R1 Y2 G5 L26 R30
External links
PDB RCSB:8uw1, PDBe:8uw1, PDBj:8uw1
PDBsum8uw1
PubMed39196936
UniProtP84233|H32_XENLA Histone H3.2

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