Structure of PDB 8urb Chain A Binding Site BS01

Receptor Information
>8urb Chain A (length=921) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMAYLNRVRGSSAARLEPCNGTDTQHVYRAFDIYNKDVACLGKFLKVNCV
RLKNLDKHDAFYVVKRCTKSAMEHEQSIYSRLEKCGAVAEHDFFTWKDGR
AIYGNVCRKDLTEYTMMDLCYALRNFDENNCDVLKSILIKVGACEESYFN
NKVWFDPVENEDIHRVYALLGTIVSRAMLKCVKFCDAMVEQGIVGVVTLD
NQDLNGDFYDFGDFTCSIKGMGIPICTSYYSYMMPVMGMTNCLASECFVK
SDIFGEDFKSYDLLEYDFTEHKTALFNKYFKYWGLQYHPNCVDCSDEQCI
VHCANFNTLFSTTIPITAFGPLCRKCWIDGVPLVTTAGYHFKQLGIVWNN
DLNLHSSRLSINELLQFCSDPALLIASSPALVDQRTVCFSVAALGTGMTN
QTVKPGHFNKEFYDFLLEQGFFSEGSELTLKHFFFAQKGDAAVKDFDYYR
YNRPTVLDICQARVVYQIVQRYFDIYEGGCITAKEVVVTNLNKSAGYPLN
KFGKAGLYYESLSYEEQDELYAYTKRNILPTMTQLNLKYAISGKERARTV
GGVSLLSTMTTRQYHQKHLKSIVNTRGASVVIGTTKFYGGWDNMLKNLID
GVENPCLMGWDYPKCDRALPNMIRMISAMILGSKHTTCCSSTDRFFRLCN
ELAQVLTEVVYSNGGFYLKPGGTTSGDATTAYANSVFNIFQAVSANVNKL
LSVDSNVCHNLEVKQLQRKLYECCYRSTTVDDQFVVEYYGYLRKHFSMMI
LSDDGVVCYNNDYASLGYVADLNAFKAVLYYQNNVFMSASKCWIEPDINK
GPHEFCSQHTMQIVDKDGTYYLPYPDPSRILSAGVFVDDVVKTDAVVLLE
RYVSLAIDAYPLSKHENPEYKKVFYVLLDWVKHLYKTLNAGVLESFSVTL
LEDSTAKFWDESFYANMYEKS
Ligand information
>8urb Chain I (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuauuaaaaucacagauu
....................
Receptor-Ligand Complex Structure
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PDB8urb An alphacoronavirus polymerase structure reveals conserved co-factor functions.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		S754 D755 R831 K844 S856
Binding residue
(residue number reindexed from 1)		S752 D753 R829 K842 S854
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8urb, PDBe:8urb, PDBj:8urb
PDBsum8urb
PubMed36993498
UniProtU6BRU0

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