Structure of PDB 8uoz Chain A Binding Site BS01

Receptor Information
>8uoz Chain A (length=110) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNPYIYLGGAILAEVIGTTLMKFSEGFTRLWPSVGTIICYCASFWLLAQT
LAYIPTGIAYAIWSGVGIVLISLLSWGFFGQRLDLPAIIGMMLICAGVLI
INLLSRSTPH
Ligand information
Ligand IDP4P
InChIInChI=1S/C24H20P/c1-5-13-21(14-6-1)25(22-15-7-2-8-16-22,23-17-9-3-10-18-23)24-19-11-4-12-20-24/h1-20H/q+1
InChIKeyUSFPINLPPFWTJW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		c1ccc(cc1)[P+](c2ccccc2)(c3ccccc3)c4ccccc4
ACDLabs 10.04c1c(cccc1)[P+](c2ccccc2)(c3ccccc3)c4ccccc4
FormulaC24 H20 P
NameTETRAPHENYLPHOSPHONIUM
ChEMBLCHEMBL1182234
DrugBank
ZINCZINC000008234386
PDB chain8uoz Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8uoz Molecular Basis of Drug Recognition by EmrE
ResolutionN/A
Binding residue
(original residue number in PDB)		F44 L47 T56 Y60 W63
Binding residue
(residue number reindexed from 1)		F44 L47 T56 Y60 W63
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015199 amino-acid betaine transmembrane transporter activity
GO:0015220 choline transmembrane transporter activity
GO:0015297 antiporter activity
GO:0022857 transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0006970 response to osmotic stress
GO:0006974 DNA damage response
GO:0009410 response to xenobiotic stimulus
GO:0015871 choline transport
GO:0031460 glycine betaine transport
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
GO:0071466 cellular response to xenobiotic stimulus
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:1990207 EmrE multidrug transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uoz, PDBe:8uoz, PDBj:8uoz
PDBsum8uoz
PubMed38806470
UniProtP23895|EMRE_ECOLI Multidrug transporter EmrE (Gene Name=emrE)

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