Structure of PDB 8umy Chain A Binding Site BS01

Receptor Information
>8umy Chain A (length=546) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPVLRRPPILEDYVHVTSTEGVRAYLVLRASSHCLWVDEFAPRHYTELLS
DDFTNRCLLKWLKLWDLVVFGHERPSSHEQVLEEMLEAGLDPSQRPKQKV
ALLCGPPGLGKTTLAHVIARHAGYSVVEMNASDDRSPEVFRTRIEAATQM
ESVLGAGGKPNCLVIDEIDGAPVAAINVLLSILNRKGLLMRPIICICNDQ
FAPSLRQLKQQAFLLHFPPTLPSRLVQRLQEVSLRQGMRADPGVLAALCE
KTDNDIRACINTLQFLYSRGQRELSVRDVQATRVGLKDQRRGLFSVWQEV
FQLPRASLTSASQRFYRVLHAAASAGEHEKVVQGLFDNFLRLRLRDSSLG
AVCVALDWLAFDDLLAGAAHHSQSFQLLRYPPFLPVAFHVLFASSHTPRI
TFPSSQQEAQNRMSQMRNLIQTLVSGIAPATRSRATPQALLLDALCLLLD
ILAPKLRPVSTQLYSTREKQQLASLVGTMLAYSLTYRQERTPDGQYIYRL
EPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVE
Ligand information
Receptor-Ligand Complex Structure
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PDB8umy Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC.
Resolution2.83 Å
Binding residue
(original residue number in PDB)		F494 P496 R499 F587 Q591 K647 H687 Q690 F692 I717 F719 Q724 Q727
Binding residue
(residue number reindexed from 1)		F201 P203 R206 F294 Q298 K330 H370 Q373 F375 I400 F402 Q407 Q410
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0032508 DNA duplex unwinding
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031390 Ctf18 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8umy, PDBe:8umy, PDBj:8umy
PDBsum8umy
PubMed38669181
UniProtQ8WVB6|CTF18_HUMAN Chromosome transmission fidelity protein 18 homolog (Gene Name=CHTF18)

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