Structure of PDB 8ujv Chain A Binding Site BS01

Receptor Information
>8ujv Chain A (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMR
AAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMP
IRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAM
CRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEER
LTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFT
VIKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB8ujv Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta.
Resolution2.23 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 S62 W64 K86 R93 K311 R313 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 S65 W67 K89 R96 K310 R312 P315 K316 T317 I318 G319 C320 S321 K322 N323 P325 R350
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8ujv, PDBe:8ujv, PDBj:8ujv
PDBsum8ujv
PubMed38413007
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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