Structure of PDB 8ujt Chain A Binding Site BS01

Receptor Information
>8ujt Chain A (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERET
GFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSL
GGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHD
PVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRND
NDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB8ujt Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 S62 K86 R93 K293 K311 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 G327 R351
Binding residue
(residue number reindexed from 1)		Q37 Y38 W41 S61 K85 R92 K285 K303 P308 K309 T310 I311 G312 C313 S314 K315 N316 P318 G319 R343
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8ujt, PDBe:8ujt, PDBj:8ujt
PDBsum8ujt
PubMed38413007
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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