Structure of PDB 8ui6 Chain A Binding Site BS01

Receptor Information

>8ui6 Chain A (length=527) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LEGAGPGRLHGRLGIKPDGQPGYTRAPSPPTDLSMPQALARGGGFNLYLS
DHLELDRTAPDARHASCRQLHYDLSTLPKASVIIVFYNEPFSTLMRSVHS
VLNGTPPQILEELILVDDGSTLPYIREDGNQQLVEYLKLLPAKVRLIRNE
VRKGIVGARMKGIRASRAPIFAILDSHIEVSPQWLEPLLLRIKEDSRRVV
MPQIDGIDAETFKHIAGGIGCKLGFLWKLMEHSYEGHQTARLPPEERQPS
PTDFQTSPAMAGGLFAANKAFFFDVGAYDEDFQFWGTENLELSFRLWQCG
GVLECAPCSRVYHIFRKGGSGYSSPGDSITINKMRTMLWMDEYADLAWRV
IGKPRVNYRPESLEKRREWRKRKGCKSFRWFMENVFPEGDVVTLDDVPYL
GPLRNDKIGMCLDNMGWASPGHAVGLEYCHGGDTQTFMFFRKVGHVMPVN
DDEACLQPSGRLDWCRGTAQFWWDFTSSGQLMFRETKQCLSAFGRKLRMV
ECDDTDPYQIWSWTAYNPPDTFTFPSV

Ligand information

>8ui6 Chain B (length=6) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GTTPSP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ui6 A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is distinct from host homologues.
Resolution	2.65 Å
Binding residue (original residue number in PDB)	G319 S334 W386 F416
Binding residue (residue number reindexed from 1)	G218 S233 W285 F315

Enzymatic activity

Enzyme Commision number

2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.

External links

PDB	RCSB:8ui6, PDBe:8ui6, PDBj:8ui6
PDBsum	8ui6
PubMed	38710711
UniProt	A0A125YMZ8

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